Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis

Table 4

Course of illness.

Course of illness
Onset of shock	Day 8
Intubated	Day 8
Vasopressor initiation	Day 8
CVVH initiated	Day 11
First bone marrow biopsy	Day 11
Imaging suggestive of acalculus cholecystitis	Day 14
Percutaneous cholecystostomy	Day 15
Liver biopsy and second bone marrow biopsy	Day 17
Extubated	Day 18
Liver biopsy reveals acute cholangitis	Day 19
HLH diagnosis made	Day 22
Initiation of HLH dexamethasone therapy	Day 22
Initiation of HLH etoposide therapy	Day 24
Repeat vasopressor initiation	Day 30
CVVH discontinued	Day 44
Discharged to rehabilitation facility	Day 56
Treatment	2 doses of etoposide 40 mg/m^2 and dexamethasone per HLH-94
Outcome	Complete remission (full recovery of cytopenias and return to baseline renal function)