Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Ophthalmological Medicine
Volume 2012 (2012), Article ID 379132, 3 pages
http://dx.doi.org/10.1155/2012/379132
Case Report

Perforating Corneal Ulceration in a Patient with Lung Metastatic Adenocarcinoma Treated with Gefitinib: A Case Report

1Ophthalmology Department, Gloucestershire Hospitals NHS Foundation Trust, Gloucestershire GL53 7AN, UK
2Oncology Department, Gloucestershire Hospitals NHS Foundation Trust, Gloucestershire GL53 7AN, UK

Received 24 October 2012; Accepted 21 November 2012

Academic Editors: D. Goldblum and P. Venkatesh

Copyright © 2012 Enjie Ibrahim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present a case of a sixty-year-old female who presented with sudden onset of painless loss of vision in one eye due to a perforated corneal ulcer, following three months of treatment with gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for metastatic adenocarcinoma of the lung with confirmed EGFR gene mutation. The eye did not show any sign of infection or inflammation and had no associated lid problems to account for the development of corneal ulceration. The patient went on to have a corneal graft surgery but postoperatively developed corneal graft melt. This paper aims to raise awareness among ophthalmologists and oncologists of the probable association between gefitinib and corneal ulceration.