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Case Reports in Ophthalmological Medicine
Volume 2015, Article ID 325485, 4 pages
Case Report

Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil

1Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA
2The Eye Institute, Tulsa, OK, USA

Received 20 February 2015; Revised 14 May 2015; Accepted 19 May 2015

Academic Editor: Hiroshi Eguchi

Copyright © 2015 Nina Ni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To present the clinical and histopathologic correlation of two cases of epithelial downgrowth (EDG) after prior intraocular surgery. Methods. Observational case reports. Results. We present two cases of EDG occurring after intraocular surgery. In both cases, after two anterior chamber injections of 5-fluorouracil (5FU), the area of EDG initially regressed. In Case 1, a limited area of EDG eventually recurred, and penetrating keratoplasty with cryotherapy was curative. In Case 2, subsequent corneal edema required Descemet-stripping automated endothelial keratoplasty, and the patient remained clinically free of EDG without further treatment. Conclusion. Intracameral 5FU may have a role in the treatment of EDG after intraocular surgery, though its precise utilization and impact remain to be defined.