Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil

Figure 1

(a) Slit lamp photograph of the right eye showing epithelial downgrowth (EDG) involving the nasal aspect of the patient’s graft (border indicated by arrows) and extending onto the superonasal native corneal endothelium. (b) Anterior chamber fluid aspirate with endothelial scraping shows the clump of squamous cells that made the diagnosis of EDG. (c) Periphery of penetrating keratoplasty specimen showing thin layer of surface epithelium (single arrow) on posterior surface of DSAEK graft. Epithelium has extended onto anterior surface of graft at left. (d) Margin of surface epithelial sheet on posterior surface of DSAEK graft. (e) Corneal epithelium and EDG on posterior cornea show similar intense immunoreactivity for cytokeratin marker AE1/AE3. (b) H&E ×400, (c) H&E ×25, (d) H&E ×250, and (e) IHC for AE1/AE3, ×50.

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