Case Report

Phenotypic Spectrum of Granular Corneal Dystrophy Type II in Two Italian Families Presenting an Unusual Granular Corneal Dystrophy Type I Clinical Appearance

Figure 1

Case , the mother. Corneal biomicroscopy at 25x magnification shows multiple round, sharply demarcated whitish granular deposits in the central cornea. Stellate opacities, though in numerical inferiority, are also detectable (a). IVCM reveals focal multiple hyperreflective circular deposits with dense aspect (maybe of amyloid origin) surrounding internal multiple irregular hyperreflective spots (maybe of hyaline origin), often surrounding the subepithelial nerve fibers (b and c). Time domain corneal OCT scan provides an overall view of the cornea with topographic detection and depth estimation of hyperreflective deposits (d).
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