Conjunctival Involvement of T-Cell Lymphoma in a Patient with Mycosis Fungoides

Figure 2

Histopathological analysis of the biopsy. (a) The conjunctiva was extensively infiltrated by atypical lymphocytes with epidermotropism (arrowhead; Hematoxylin and Eosin [H and E], 200x). (b) At higher magnification, the tumor showed atypical small to medium sized lymphocytes with irregular nuclei and clumped chromatin (arrow). Macrophages and reactive lymphocytes were also seen (H and E, 400x). (c) The neoplastic cells were positive for CD3 (200x). (d) Decreased coexpression by the neoplastic lymphocytes was noticed (100x). (e) CD20 was only expressed by the scattered reactive B-cells (100x). (f) Proliferative index estimated by nuclear positivity for KI-67 antigen was approximately 20% (400x).

(a)

(b)

(c)

(d)

(e)

(f)