Case Reports in Orthopedics

Case Reports in Orthopedics / 2016 / Article

Case Report | Open Access

Volume 2016 |Article ID 3621749 |

Thomas Pommepuy, Adrien Lons, Kevin Benad, Eric Beltrand, Eric Senneville, Henri Migaud, "Bilateral One-Stage Revision of Infected Total Hip Arthroplasties: Report of Two Cases and Management of Antibiotic Therapy", Case Reports in Orthopedics, vol. 2016, Article ID 3621749, 3 pages, 2016.

Bilateral One-Stage Revision of Infected Total Hip Arthroplasties: Report of Two Cases and Management of Antibiotic Therapy

Academic Editor: Johannes Mayr
Received02 Jul 2015
Revised27 Dec 2015
Accepted29 Dec 2015
Published19 Jan 2016


Recommendations for the management of chronic and bilateral total hip arthroplasty (THA) infection are lacking. However, this type of infection involves medical problems concerning the management of the antibiotic therapy. We report two cases of such infections operated as one-stage revision. For each case, both hips were infected with the same bacteria (Staphylococcus caprae for one patient and methicillin-sensitive Staphylococcus aureus for the other). The probabilistic antibiotic treatment started during the first side (after harvesting intraoperative samples) did not prevent the culture of the bacteriologic harvested during the intervention of the second side. Cultures were positive for the same bacteria for both sides in the two cases presented herein. After results of intraoperative cultures, patients received culture-guided antibiotic therapy for three months and were considered cured at the end of a two-year follow-up. Our results suggest one-stage bilateral change of infected THA is a viable option and that early intraoperative antibiotic, started during the first-side exchange, does not jeopardize microbiological documentation of the second side. This work brings indirect arguments, in favor of the use of prophylactic antibiotics during revision of infected THA.

1. Introduction

Total hip arthroplasty (THA) infections occur in 0.5 to 3% of patients, and may account for a third of reoperations and require multidisciplinary management [13]. Bilateral infections remain sporadic without clear recommendations. The large study from the Société Française d’Orthopédie-Traumatologie (SOFCOT) reported only 3 bilateral out of 691 THA infections and recommended a two-stage strategy, but no guideline was given for the antibiotic therapy in such situations [4]. This issue was not addressed in the document of the recent International Consensus Meeting on Prosthetic Joint Infections (ICMPJI) [5]. It is largely admitted that a microbiological documentation is essential to manage such chronic infections [35]. Choosing a one-stage approach with bilateral replacement in the same session requires intraoperative administration of antibiotics before correcting the second side which may lead to false negative bacterial cultures on the second side. [36]. Facing two cases of bilateral infection we made the choice of one-stage strategy and we started probabilistic antibiotics intraoperatively for the first side before the change of the second side. We found it interesting to study these two cases to evaluate the influence of antibiotics on the culture of intraoperative samples and so to argument for prophylactic antibiotics during revision of infected THA.

2. Observation

The first case was a sixty-year-old male, with an American Society of Anesthesiology (ASA) score of 2 and history of bilateral arthroplasty in 2009 and 2010 done at another institution. He was refereed to our center in 2011 for bilateral hip pain and was suspected of presenting chronic infection, because of radiological signs of intense femoral periosteal reaction (Figure 1(a)). Joint aspiration confirmed the diagnosis, identifying Staphylococcus caprae in both hips. The patient underwent a bilateral change in one stage with the administration of broad-spectrum empiric antibiotic therapy as soon as surgical samples were taken on the first side. Replacement of the second side was conducted with the same protocol. Microbiological cultures of both hips were positive with the same bacteria (Staphylococcus caprae sensitive to methicillin) found on four samples out of six, on standard and Rosenow’s growth medium enriched cultures [7] (Table 1).

Case  1Case  2
Left hipRight hipLeft hipRight hip
Date of index surgery2009201020062009

Indication for THAPrimary osteoarthritis
ASA score 22
CRP level at diagnosis ( mg/L)18 mg/L81 mg/L
White blood cells count (–10000/mm3)11700/mm312500/mm3
Neutrophil polynuclear cells count (–8000/mm3)9360/mm39850/mm3
Date of joint aspiration 02/11/201102/11/201102/07/201214/07/2012
Bacteria at cultureStaphylococcus caprae sensitive to ⁢methicillin (coagulase negative)⁢Methicillin-sensitive
Staphylococcus aureus (MSSA)
Date of 1-stage bilateral revision21/11/201106/08/2012
Delay from probabilistic ATB to sample collection in the second hip180 minutes180 minutes
Probabilistic ATB Cefepime + daptomycinCefotaxime + vancomycin
Culture-guided ATB debuted intravenously on day 5 for 5 days and then switched to oral for 10 weeksRifampicin + levofloxacin Rifampicin + levofloxacin
Positivity of culture samples on the second side⁢Same bacteria
4 out of 6 samples
(3 Rosenow’s broth and 1 standard)
⁢Same bacteria
4 out of 6 samples
(2 Rosenow’s broth and 2 standard)
CRP at the time of withdrawal of antibiotic therapy ( mg/L)5 mg/L3 mg/L
Intraoperative bleeding 1200 cc1600 cc
Posttreatment follow-up duration36 months24 months

ATB: antibiotics therapy; CRP: C-reactive protein.

The second case was a sixty-year-old female, with an ASA score of 2 and history of bilateral arthroplasty in 2006 and 2009, who consulted in 2012 for left hip pain associated with systemic inflammatory reaction (Table 1). Microbiological cultures of the left hip liquid aspiration were positive with methicillin-sensitive Staphylococcus aureus (MSSA). Three weeks later, right hip pain occurred that justified a joint aspiration from the hip in which the same MSSA strain according to the antibiotype was identified. The patient underwent bilateral hip change in one stage according to same surgical and antibiotic therapy protocols as the first case. Cultures of the two hips were positive with the same bacteria (MSSA) on four samples out of six, on standard and Rosenow’s growth medium enriched cultures [7].

The pathogens identified during hip aspiration were sensitive to the probabilistic antibiotics. Both cases received the same antibiotic treatment adapted to their antibiograms (rifampicin + levofloxacin) introduced on day 5 for five days intravenously and then for three months per os regimen. At the end of a three-year (case one) and two-year (case two) follow-up, the functional Oxford score [8] was, respectively, 12/60 and 18/60, their CRP was normal, and periosteal reaction had dropped for case one (Figure 1(b)).

3. Discussion

Both cases suggest that it seems possible, with a satisfactory microbiological documentation and therefore culture-guided appropriate antibiotic therapy, to perform bilateral one-stage replacement of infected THA. Former studies were in favor of a two-stage revision to manage bilateral infected hip arthroplasties [4], but repeated surgery and an incapacity period due to two-stage replacement led us to prefer the option of one-stage surgery [3, 5, 6].

In the two cases presented above, there are some practical problems. Firstly, the one-stage revision option implies potential surgical risks. However, our patients had low morbidity with an ASA score of 2 and our surgery protocol was strict (change of all prosthesis components and intensive debridement of the surgical site). One-stage strategy allows sterilizing all septic sites and reduces cost (a single hospitalization and antibiotics therapy, a shorter nonworking period) and faster rehabilitation. Secondly, we believe there is a risk of contamination of the nonreplaced side, when the replacement is unilateral. Thirdly, the probabilistic antibiotic therapy could have resulted in false negative culture of the second hip, though it was not reported in our cases. The two cases of the present study advocate the use of antibiotic prophylaxis in case of THA revision for infection [6, 9]. It is however difficult to definitely conclude on this last point as the microbiological documentation is of paramount importance in the management of prosthetic joint infections [5, 6, 9].

The informed consent of the patients was obtained for this study.

Conflict of Interests

Eric Senneville is Consultant for Novartis and Pfizer and Speaker for Sanofi-Aventis, AstraZeneca and Gilead. H. Migaud acts as an Educational and Research Consultant for Tornier and Zimmer. The remaining authors declare no conflict outside of the current study.


The authors thank Nicolas Krantz for his active participation in this work and Marie Titecat and Caroline Loiez for their technical assistance.


  1. N. Reina, C. Delaunay, P. Chiron, N. Ramdane, and M. Hamadouche, “Infection as a cause of primary total hip arthroplasty revision and its predictive factors,” Orthopaedics and Traumatology: Surgery and Research, vol. 99, no. 5, pp. 555–561, 2013. View at: Publisher Site | Google Scholar
  2. M. D. Wimmer, T. M. Randau, S. Petersdorf et al., “Evaluation of an interdisciplinary therapy algorithm in patients with prosthetic joint infections,” International Orthopaedics, vol. 37, no. 11, pp. 2271–2278, 2013. View at: Publisher Site | Google Scholar
  3. L. Legout and E. Senneville, “Periprosthetic joint infections: clinical and bench research,” The Scientific World Journal, vol. 2013, Article ID 549091, 17 pages, 2013. View at: Publisher Site | Google Scholar
  4. C. Vielpeau and A. Lortat Jacob, “Infection of total hip replacement,” Revue de Chirurgie Orthopopédique et Réparatrice de l'Appareil Locomoteur, vol. 88, supplement 5, pp. 161–206, 2002. View at: Google Scholar
  5. M. Ollivier, E. Senneville, M. Drancourt, J.-N. Argenson, and H. Migaud, “Potential changes to French recommendations about peri-prosthetic infections based on the international consensus meeting (ICMPJI),” Orthopaedics and Traumatology: Surgery and Research, vol. 100, no. 6, pp. 583–587, 2014. View at: Publisher Site | Google Scholar
  6. J.-Y. Jenny, R. Lengert, Y. Diesinger, J. Gaudias, C. Boeri, and J.-F. Kempf, “Routine one-stage exchange for chronic infection after total hip replacement,” International Orthopaedics, vol. 38, no. 12, pp. 2477–2481, 2014. View at: Publisher Site | Google Scholar
  7. E. Senneville, C. Savage, I. Nallet et al., “Improved aero-anaerobe recovery from infected prosthetic joint samples taken from 72 patients and collected intraoperatively in Rosenow's broth,” Acta Orthopaedica, vol. 77, no. 1, pp. 120–124, 2006. View at: Publisher Site | Google Scholar
  8. C. Delaunay, J.-A. Epinette, J. Dawson, D. Murray, and B.-M. Jolles, “Cross-cultural adaptations of the Oxford-12 HIP score to the French speaking population,” Orthopaedics & Traumatology: Surgery & Research, vol. 95, no. 2, pp. 89–99, 2009. View at: Publisher Site | Google Scholar
  9. M. W. Tetreault, N. G. Wetters, V. Aggarwal, M. Mont, J. Parvizi, and C. J. Della Valle, “The Chitranjan Ranawat Award: should prophylactic antibiotics be withheld before revision surgery to obtain appropriate cultures?” Clinical Orthopaedics and Related Research, vol. 472, no. 1, pp. 52–56, 2014. View at: Publisher Site | Google Scholar

Copyright © 2016 Thomas Pommepuy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles