Scedosporium prolificans Septic Arthritis and Osteomyelitis of the Hip Joints in an Immunocompetent Patient: A Case Report and Literature Review

Table 1

Reported Scedosporium prolificans-associated osteomyelitis and/or septic arthritis infections from penetrating trauma in immunocompetent patients.

Age/gender	Location	Mechanism of introduction	Site/presentation	Treatments used	Final Outcome	Author/Year
6/M	North America	Penetrating injury	Foot osteomyelitis	Surgical debridement, Amphotericin B, Ketoconazole, Miconazole,	Improvement	Taj-Aldeen et al. 2015 [9]
3/M	South America	Trauma	Knee septic arthritis	Surgery, Ketoconazole,; Amphotericin B,; Ketoconazole, intra-articular; Amphotericin B, intra-articular Miconazole	Amputation	Wilson et al. 1990 [19]
5/M	North America	Penetrating trauma from thorn	Knee septic arthritis	Surgery, Amphotericin B; 5-FC, intra-articular Amphotericin B,; Miconazole, Ketoconazole	Improvement	Wilson et al. 1990 [19]
54/M	North America	Trauma from axe	Knee arthritis	Surgery, Amphotericin B,; Ketoconazole; Miconazole	Improvement	Wilson et al. 1990 [19]
6/M	North America	Penetrating injury from nail	Foot osteomyelitis	Surgical debridement	Improvement	Wilson et al. 1990 [19]
6/M	North America	Penetrating injury from nail	Foot osteomyelitis	Surgery, Amphotericin B,; Ketoconazole	Improvement	Wilson et al. 1990 [19]
35/M	North America	Penetrating injury/IV drug use	Hip septic arthritis	Joint drainage, Amphotericin B,; 5-fluorocytosine	Improvement	Wilson et al. 1990 [19]
11/M	Australia	Laceration	Ankle septic arthritis	Surgical debridement, Amphotericin B, Itraconazole	Improvement	Wood et al. 1992 [11]
5/M	North America	Penetrating injury from nail	Foot osteomyelitis	Surgical debridement, polyhexamethylene, biguanide, Voriconazole, caspofungin	Improvement	Steinbach et al. 2003 [3]
9/M	Sweden	Penetrating injury from thorn	Knee osteomyelitis	Surgical debridement, cefuroxime, Amphotericin B, Itraconazole, Voriconazole	Improvement with arthrodesis	Studahl et al. 2003 [15]
5/M	Australia	Ankle abrasion due to trauma	Ankle septic arthritis	Surgical debridement, Amphotericin B, Itraconazole, Terbinafine, Voriconazole	Improvement	Dalton et al. 2006 [13]
8/F	Australia	Trauma from tractor	Hip osteomyelitis and hip septic arthritis	Surgical debridement,; Hexadecylphosphocholine, Terbinafine, Voriconazole	Improvement	Kesson et al. 2009 [16]
4/M	United Kingdom	Penetrating injury from thorn	Foot osteomyelitis	Surgical debridement, Voriconazole, Terbinafine	Improvement	Bhagavatula et al. 2014 [14]
54/M	Australia	Penetrating injury from HCLA injections	Hip osteomyelitis and hip septic arthritis	2-stage total-hip-arthroplasty with Voriconazole-loaded cement and spacer, Voriconazole, Terbinafine	Improvement	Daniele et al. 2016