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Case Reports in Orthopedics
Volume 2017, Article ID 7402570, 6 pages
Case Report

Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases

1Orthopaedic Surgery, Leiden University Medical Center, Leiden, Netherlands
2Orthopaedic Surgery, Radboud University Medical Center, Nijmegen, Netherlands

Correspondence should be addressed to Monique J. L. Mastboom; ln.cmul@moobtsam.l.j.m

Received 8 February 2017; Revised 23 April 2017; Accepted 16 May 2017; Published 28 June 2017

Academic Editor: Koichi Sairyo

Copyright © 2017 Monique J. L. Mastboom et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remain unclear. Surgical resection is the most commonly performed treatment. Unfortunately, recurrences often occur (up to 92%), necessitating reoperations and adjuvant treatments. Once all treatments fail or if severe complications occur, limb amputation may become unavoidable. We describe four cases of above-knee amputation after TGCT diagnosis.