Continuous Local Antibiotics Perfusion Therapy for Acute Deep Infections after Open Fractures

Table 2

Summary of management and clinical results.

Patient number	Duration of CLAP (days)	Surgical intervention	Systemic antibiotics	CRP (mg/dL); Pre	CRP (mg/dL); Post^†	Outcomes		Follow-up (months)
						Recurrence	Bone union
1	12	Debridement	TAZ/PIPC, 15 days	4.20	2.84	No	Yes	45
2	10	Debridement	MINO, 10 days	0.57	0.12	No	Yes	45
3	8	Debridement	CEZ, 11 days	0.64	0.13	No	Yes	46
4	7	Debridement	SBT/ABPC, 8 days	1.96	0.76	No	Yes	20
5	9	Debridement	CEZ, 29 days	8.40	0.44	No	Yes	18
6	11	Debridement	SBT/ABPC, 21 days	5.46	4.22	No	Yes	43
Average	9.5			3.54	1.42			36

CLAP: continuous local antibiotic perfusion; CRP: C-reactive protein; TAZ/PIPC: tazobactam/piperacillin; MINO: minocycline; CEZ: cefazolin; SBT/ABPC: sulbactam/ampicillin; “Pre” indicates immediately before starting CLAP therapy. ^†“Post” indicates within two days after finishing CLAP therapy.