Criteria for radiation-induced malignancy.
|(1) The site of origin must be within the field of previous radiation|
|(2) The patient should have received a significant amount of radiation therapy (greater than 2,500 rads)|
|(3) An interval of at least 3–5 years must elapse between the time of irradiation and the development of the sarcoma|
|(4) The second primary cancer needs to be histologically different from the primary neoplasm|