Case Reports in Otolaryngology / 2012 / Article / Tab 3

Case Report

A Case of Radiation-Induced Multifocal Laryngeal Angiosarcoma Presenting as a Diagnostic Dilemma

Table 3

Criteria for radiation-induced malignancy.

(1) The site of origin must be within the field of previous radiation
(2) The patient should have received a significant amount of radiation therapy (greater than 2,500 rads)
(3) An interval of at least 3–5 years must elapse between the time of irradiation and the development of the sarcoma
(4) The second primary cancer needs to be histologically different from the primary neoplasm