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Case Reports in Otolaryngology
Volume 2012, Article ID 405824, 3 pages
http://dx.doi.org/10.1155/2012/405824
Case Report

Acquired Form of Angioedema of the Head and Neck Related to a Deficiency in C1-Inhibitor: A Case Report with a Review of the Literature

1Department of Otorhinolaryngology, University Hospital CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
2Department of Otorhinolaryngology, Cantonal Hospital Fribourg, Fribourg, Switzerland

Received 4 October 2012; Accepted 30 October 2012

Academic Editors: A. Casani and S. Ulualp

Copyright © 2012 Bassel Hallak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Angioedema related to a deficiency in the C1-inhibitor protein is characterized by its lack of response to therapies including antihistamine, steroids, and epinephrine. In the case of laryngeal edema, mortality rate is approximately 30 percent. The first case of the acquired form of angioedema related to a deficiency in C1-inhibitor was published in 1972. In our paper, we present a case of an acquired form of angioedema of the oropharyngeal region secondary to the simultaneous occurrence of two causative factors: neutralization of C1-inhibitor by an autoantibody and the use of an angiotensin convertin enzyme inhibitor.