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Case Reports in Otolaryngology
Volume 2015, Article ID 308743, 3 pages
http://dx.doi.org/10.1155/2015/308743
Case Report

Immunophenotype Heterogeneity in Nasal Glomangiopericytoma

1APHP, Université Paris Nord Sorbonne Cité, 93009 Bobigny, France
2Tulane Medical School, New Orleans, LA 70118, USA
3Evaggelismos General Hospital, 10675 Athens, Greece
4Institut Curie, 75005 Paris, France

Received 11 May 2015; Accepted 6 August 2015

Academic Editor: Yorihisa Orita

Copyright © 2015 Adriana Handra-Luca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nasal glomangiopericytoma is rare. The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive. We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma. The patient (woman, 86 years) presented with a left nasal tumefaction. The resected specimen (1.5-cm) showed a glomangiopericytoma. Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor. They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR. Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation. The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.