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Case Reports in Otolaryngology
Volume 2015, Article ID 916023, 4 pages
Case Report

HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil

1Division of Otorhinolaryngology, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy
2Hygiene and Preventive Medicine, Department of Biomedical Sciences, University of Sassari, Sassari, Italy
3ENT Department, P. Dettori Hospital, Tempio Pausania, Italy
4Department of Head and Neck Surgery, Poole Hospital NHS Foundation Trust, Poole, UK

Received 19 August 2015; Revised 11 November 2015; Accepted 16 November 2015

Academic Editor: Kamal Morshed

Copyright © 2015 Virginia Fancello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with HPV types 6 and 18. The tetravalent HPV vaccine Gardasil was prescribed off label, with the aim of triggering an immunogenic response and consequently reducing the probability of further recurrences. The patient was followed for 9 months with no sign of relapse of his LP. The postexposure use of the anti-HPV vaccine could represent a promising therapeutic agent in established LP. Unfortunately, the potential efficacy of this new therapeutic option in this situation has been suggested only by isolated case reports. Further controlled studies, with a longer follow-up and a larger sample size, are needed to assess efficacy of Gardasil in LP.