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Case Reports in Otolaryngology
Volume 2017, Article ID 7296467, 4 pages
Case Report

High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant

1Department of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi Arabia
2Department of Pathology, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia

Correspondence should be addressed to Sarah S. Al-Otaibi; moc.kooltuo@ibiatolass

Received 6 January 2017; Revised 1 April 2017; Accepted 19 April 2017; Published 14 May 2017

Academic Editor: Abrão Rapoport

Copyright © 2017 Sarah S. Al-Otaibi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.