Case Reports in Otolaryngology

Case Reports in Otolaryngology / 2019 / Article

Case Report | Open Access

Volume 2019 |Article ID 3041570 | 5 pages | https://doi.org/10.1155/2019/3041570

A Case of Inverted Papilloma Originating from the Middle Ear and Review of the Literature

Academic Editor: Seckin Ulualp
Received10 Jan 2019
Accepted09 Jun 2019
Published24 Jul 2019

Abstract

Inverted papilloma (IP) with malignant transformation is rarely seen in the middle ear. Up to now, there have been 16 primary middle ear IPs reported in the English literature. Even though it is very rare in the middle ear, this pathology should be kept in mind for the differential diagnosis of middle ear masses. In this case, we report a 77-year-old female who had recurrent IP with malignant transformation and complication.

1. Introduction

Inverted papilloma (IP) is a rare benign tumor that can show recurrence. It constitutes 0.5–4% of nasal tumors [13]. It mainly originates from the lateral nasal wall near the middle meatus and often extends to the paranasal sinus [1]. This lesion is locally invasive and has a tendency toward malignant transformation [3, 4]. Inverted papilloma in the middle ear and mastoid cavity might occur extremely rarely as a primary lesion or as an extension of a sinonasal papilloma [3]. IP may have a high degree of dysplasia, and 2–27% of patients may develop invasive squamous cell carcinoma (SCC) [5, 6]. The recurrence and malignancy rates of IP in the middle ear are higher than the rates of sinonasal IP [7]. Radiotherapy or chemotherapy, two of the most common treatment methods, is applied after surgical excision of IP [3]. To date, the number of reported primary IP cases originating from the middle ear and mastoid cavity is 16 in the English literature [4, 718]. In this case report, we present a primary middle ear PA and discuss this along with comparisons to reports in the literature.

2. Case Presentation

A 77-year-old female patient who had right tympanomastoidectomy operations twice in another hospital with the diagnosis of chronic otitis media with cholesteatoma was admitted to our clinic with a complaint of discharge in the right ear. The right external auditory canal was filled with a cholesteatomatous mass. On diffusion-weighted temporal bone MRI, soft tissue images showing peripheral contrast enhancement were seen in the right mastoid cells, mastoid antrum, and middle ear. There was no restriction in diffusion-weighted imaging of this lesion, and thus, cholesteatoma was not considered as a diagnosis (Figures 1 and 2). The patient’s temporal bone CT images were reported as soft tissue obliterating the right external ear canal, showing extension to the middle ear cavity, causing destruction in the ossicular chain, mastoid antrum, tegmen tympani, and mastoideum (Figure 3). No sinonasal pathology was found in the patient’s history. Examination and imaging of the sinonasal region showed no additional pathology (Figure 4). There was advanced sensorineural hearing loss on audiologic evaluation. The patient reported having had hearing loss for many years. In the left ear, both bone conduction and air conduction were 37 dB. Canal wall-down tympanomastoidectomy was performed under general anesthesia. All pathological tissues were cleaned, and because there were no perioperative or postoperative problems, the patient was discharged on postoperative day 2 and asked to return for a routine follow-up visit. The histopathological diagnosis was granulation tissue.

About 6 months after the operation, the patient came back because of recurrence of ear discharge. There was a cholesteatomatous mass observed by otomicroscopic evaluation. Revision surgery was performed, and partial petrosectomy and cavity obliteration of the fatty tissue were done. Histopathologic evaluation of the cleaned tissues was reported as cholesteatoma.

Two months after the operation, the patient was admitted to the clinic with a vegetative mass in the postauricular scar area. She also had grade 5 facial paralysis according to the House–Brackmann classification on the right side. The patient was hospitalized again, and revision surgery was performed under general anesthesia. There was an ulcerovegetan mass filling the mastoid area (Figure 5) and eroding bone on the horizontal and vertical facial canal. It was observed that the pathology proceeded to the medial line of the petrous bone. Since the dura was completely exposed, the neurosurgery team was included in the operation. All lesions were cleared, and total petrosectomy was performed. The damaged dura was repaired. The operation was terminated by obliterating the cavity containing the fat tissue. Pathologic evaluation of the specimen was reported as “IP-high grade squamous dysplasia” (Figure 6). The patient received a dose of 16 gy in 8 fractions. Radiotherapy could not be continued because of deterioration of the patient’s general medical condition. General health problems worsened, and 4 months after the last operation, the patient passed away due to multiple organ failure.

3. Discussion

IP generally originated from the epithelium of paranasal sinuses. [4, 19, 20]. The nasal cavity and paranasal sinuses are covered with a columnar epithelium which is called the Schneiderian epithelium [8, 20]. Thus, a paranasal sinus papilloma is known as a Schneiderian papilloma [6]. IP is the most common subtype of Schneiderian papilloma [7, 19, 20].

The etiology of IP is not clearly understood. Allergic rhinitis, chronic sinusitis, and human papilloma virus (HPV) infection have been discussed as etiologic factors [1, 3]. Blandamura et al. investigated some sex hormones in IPs that had formed in paranasal sinuses and temporal bones and reported progesterone receptor expression in some of these cases [9]. Although there was no progesterone receptor expression, p16 and p27 genes were positive in the current case (Figures 7 and 8).

IP is a locally aggressive tumor, and transformation to squamous cell carcinoma may be seen [2123]. Vorasubin et al. reported SCC in 3 of 70 cases (8%) with inverted papilloma originating from sinonasal origins. Dysplastic changes also were present in 3 (8%) of the patients [24]. In another study by Barnes, the incidence of malignancy was reported as 11% [25]. The histopathological diagnosis of the current case was IP-high grade squamous dysplasia.

Middle ear or mastoid cavity IP may be in 2 forms. Sinonasal IP may extend into the middle ear, or it may be middle ear-based without any history of sinonasal IP [26]. Primary IPs originating from the mastoid cavity or middle ear are extremely rare [27]. To date, other than our case, the number of cases reported as middle ear- or mastoid-based IP is 16 in the English literature (Table 1). If sinonasal IPs with middle ear involvement are included, this number increases to 39.


No.Literature referenceAgeSexLocationMTTreatmentRecurrence
YesNoSurgRTYesNo

1Roberts et al. [11]19FME+++
2Wenig [12]31FME+++
3Wenig [12]56FMC, ME+++
4Wenig [12]19FME+++
5Wenig [12]57FME+++
6Chhetri et al. [13]26FEAC, ME+++
7de Filippis et al. [15]58MMC, ME+++
8Blandamura et al. [9]54FME++NANA
9Cahali et al. [10]72MME, EAC+++
10Ali et al. [14]42FMC, ME, EACNANA++
11Zhou et al. [16]52MMC, ME, EAC+++
12van der Putten et al. [7]74FMC, EAC++NANA
13Coca-Pelaz et al. [4]74MME++NANA
14Schaefer et al. [18]46MME, MC+++
15Nath and Das [17]60MMC++++
16Mummadi et al. [8]60MMC, ME+++NANA
17Current case77FMC, ME, EAC++++

M: male; F: female; MC: mastoid cavity; ME: middle ear; EAC: external auditory canal; RT: radiotherapy; MT: malignant transformation; Surg: surgery; RT: radiotherapy; N/A: not applicable.

The mean age of these 17 primary middle ear- or mastoid-originated cases is 51 years. Malignant transformation occurred in 23.5% of cases, and the recurrence rate was 17.6% in these 17 patients. These rates are higher than the rates which were reported as 7% for malignant transformation of sinonasal IP and 15% for the recurrence rate of sinonasal IP [19]. Both recurrence and malignant transformation were seen in the current case.

Although the pathogenesis of IP in the middle ear and the mastoid cavity is not clearly understood, two hypotheses have been discussed. One of them is direct extension of sinonasal pathology, and the other is abnormally displaced embryonic Schneiderian membrane into the middle ear [12]. In the current case, since no pathological appearance on evaluation of the sinonasal zone could be detected, it was thought that the disease had developed as a result of abnormal embolization of embryonic Schneiderian membrane into the middle ear.

Surgery is the preferred method of treatment for middle ear and mastoid IP [2, 3, 19]. It is difficult to define a standard surgical strategy based on the limited data available in the literature. Tympanomastoidectomy, radical temporal bone resection, or petrosectomy may be preferred depending on the location of the disease [2]. Total petrosectomy was performed in our last surgery, where the case was diagnosed as IP. Radiotherapy could be added if the tumor is not fully resected or if there is more than one recurrence, even without malignancy [2]. Since our patient had both recurrence and malignant transformation, we planned complementary treatment with radiotherapy. However, the general health status of the patient did not allow for completion of radiotherapy, and she died from multiorgan failure.

In conclusion, even though it is very rare, IP can be seen in the middle ear. This pathology with local recurrence and malignant transformation potential should be considered in the differential diagnosis of recurrent middle ear diseases.

Disclosure

This study was presented at the 39th Turkish National Otorhinolaryngology & Head and Neck Surgery Congress, 7–11 December 2018, Antalya, Turkey, and XI Congress of Otorhinolaryngology, 31 May to 3 June 2018, Varna, Bulgaria.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Acknowledgments

The authors thank Prof. Gazanfer Ekinci, M.D., from the Marmara University Department of Radiology, for evaluating and commenting on radiological images.

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Copyright © 2019 Eray Bayindir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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