Acquired Hemophilia A Presenting as Massive Postoperative Bleeding in a Patient with Oral Squamous Cell Carcinoma

Table 1

Summary of reported cases of acquired hemophilia A with head and neck cancer.

Patient #	Age(years)/sex	Disease	Inhibitor titer (BU)	FVIII (%)	Bleeding control	Immunosuppression	Time of onset	Bleeding control outcome	Inhibitor eradication	Reference
1	73/F	Epiglottis (SCC)	8	<1	PCC	Hc, C, PLEX, IVIG	Presurgery	CR	CR	Shastri et al. [11]
2	73/M	Larynx	11	NA	NA	R, P	Postsurgery in cancer remission	CR	CR	Onitilo et al. [12]
3	37/M	Oral (SCC)	12	1	rFVIII, aPCC, rFVIIa	Mp	Day 29 after surgery	CR	NA	Chen et al. [13]
4	46/M	Oral (SCC)	2	4	rFVIIa	P	Day 1 after surgery	CR	PR	Present case

F, female; M, male; SCC, squamous cell carcinoma; BU, Bethesda units; FVIII, coagulation factor VIII; NA, not available; PCC, prothrombin complex concentrates; rFVIII, recombinant activated factor VIII; aPCC, activated prothrombin complex concentrate; rFVIIa, recombinant activated factor VII; Hc, hydrocortisone; C, cyclophosphamide; PLEX, plasma exchange; IVIG, intravenous immunoglobulin; R, rituximab; P, prednisolone; Mp, methylprednisolone; CR, complete response; PR, partial response.