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Case Reports in Pathology
Volume 2012, Article ID 284064, 3 pages
Case Report

Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma

1Service de Pathologie Clinique, Hôpitaux Universitaires de Genève, 1211 Geneva, Switzerland
2Division of Gastroenterology, “G. Fracastoro” City Hospital, Verona, Italy

Received 29 July 2012; Accepted 25 September 2012

Academic Editors: S.-I. Motegi, M. M. Picken, and T. Strecker

Copyright © 2012 Giacomo Puppa and Mariella Molaro. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.