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Case Reports in Pathology
Volume 2012, Article ID 579245, 3 pages
Case Report

Malignant Fibrous Histiocytoma of the Breast: A Case Report

1Laboratory of Histology and Embryology, Aristotle University of Thessaloniki School of Medicine, 54006 Thessaloniki, Greece
2Department of Pathology, Geniki Kliniki, 54645 Thessaloniki, Greece
3Department of Obstetrics and Gynaecology, Geniki Kliniki, 54645 Thessaloniki, Greece

Received 6 December 2011; Accepted 15 January 2012

Academic Editor: S. Shousha

Copyright © 2012 Dimosthenis Miliaras and Emmanouel Konstantinides. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper concerns a case of Malignant Fibrous Histiocytoma (MFH) of the Breast in a 73-years-old woman. A lump was found in her right breast, measuring 1.7 cm in diameter. Surgical excision followed, and pathology revealed a highly atypical spindle cell tumor. Immunohistochemistry along the histological features, excluded the possibility of carcinoma, malignant phyllodes tumor, or another type of pure sarcoma. There was no history of previous irradiation in the region. MFH is among the rarest types of sarcoma of the breast, and most of the times behaves aggressively. Excision with wide, free-of-tumor margins is the most effective treatment, when feasible.