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Case Reports in Pathology
Volume 2013, Article ID 853095, 6 pages
Case Report

Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

1Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, Iran
2Department of Pathology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, Iran

Received 11 May 2013; Accepted 1 July 2013

Academic Editors: I. A. Chaudhry, H. Kuwabara, and E. Miele

Copyright © 2013 Sepideh Mokhtari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Calcifying cystic odontogenic tumor (CCOT) demonstrates considerable diversity in histopathology and clinical behavior. Ghost cell odontogenic carcinoma (GCOC) is the rare malignant counterpart of CCOT and it frequently arises from malignant transformation of a recurrent CCOT. In this paper, we present a case of CCOT and discuss its distinct histopathologic features in recurrence. Then, we will have a review on clinical, histopathological, and immunohistochemical aspects of GCOC in the literature. Predictive factors of malignant transformation in a benign CCOT will also be discussed.