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Case Reports in Pathology
Volume 2014, Article ID 238545, 5 pages
Case Report

Rhabdomyosarcoma with Pseudolipoblasts Arising in Ovarian Carcinosarcoma: A Distinctive Postchemotherapy Morphologic Variant Mimicking Pleomorphic Liposarcoma

1Sarcoma Unit, Royal Marsden Hospital, London SW3 6JJ, UK
2Department of Histopathology, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK
3Gynaecology Unit, Royal Marsden Hospital, London SW3 6JJ, UK

Received 2 October 2013; Accepted 8 December 2013; Published 22 January 2014

Academic Editors: Y. Dobashi, D. Miliaras, Y. Nagashima, and D. Vlachodimitropoulos

Copyright © 2014 Khin Thway et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe a case of ovarian carcinosarcoma occurring in a 60-year-old female. The neoplasm was excised after neoadjuvant chemotherapy and contained a predominant heterologous pleomorphic rhabdomyosarcomatous component in which there were numerous multivacuolated rhabdomyoblasts that strongly mimicked lipoblasts. The clear cell variant of rhabdomyosarcoma is rarely documented, but this case shows a highly unusual finding in which the rhabdomyoblasts show the prominent multivacuolation with nuclear indentation characteristic of and indistinguishable from pleomorphic lipoblasts. This appears to represent a posttreatment phenomenon. As this finding might conceivably occur in other rhabdomyosarcomas after chemotherapy, we highlight the potential for diagnostic confusion with pleomorphic liposarcoma, which is usually diagnosed by morphology so that immunohistochemistry for muscle markers might not be performed.