Small Intestinal Amyloidosis: A Rare Cause of Diverticular Disease
Figure 1
(a) Whole mount section of the small intestine showing diverticular disease (hematoxylin and eosin stained section, magnification 8). (b) and (c) show extensive deposition of eosinophilic amorphous material (amyloid) in the muscularis mucosa, submucosa, and muscularis propria layers of the small bowel. Ischemic mucosal ulceration and hemorrhages are present in (c) (hematoxylin and eosin stained sections, (b) magnification 40 and (c) magnification 20). (d) Congo red stain under polarized light shows extensive green birefringence, diagnostic of amyloid deposition (magnification 2). (e) Immunostain for kappa light chain shows extensive AL amyloid deposition within the muscularis mucosa, muscularis propria, and blood vessel walls (magnification 10).
