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Case Reports in Pathology
Volume 2014 (2014), Article ID 971464, 5 pages
Case Report

Small Cell Carcinoma of the Uterine Cervix in a Pregnant Patient Diagnosed with Liquid Based Cytology and Cell Block Immunocytochemistry

1Duke University, Durham, NC 27708, USA
2CellNetix Pathology and Laboratories, Everett, WA 98201, USA
3Providence Regional Medical Center Everett, Everett, WA 98201, USA
4The Everett Clinic, Everett, WA 98201, USA
5Cleveland Clinic, Robert J. Tomsich Pathology Institute, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA

Received 20 June 2014; Accepted 8 August 2014; Published 28 August 2014

Academic Editor: Tibor Tot

Copyright © 2014 Mawuli F. Attipoe and Charles D. Sturgis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visits. Only rare case reports of small cell carcinoma arising in gravid cervices are known. In the current case a 29-year-old, gravida 6, para 2, pregnant (10-week gestation) female presented with postcoital bleeding. A definitive diagnosis of small cell carcinoma of the cervix was made possible by liquid based Pap testing with ancillary cell block preparation allowing for immunocytochemical characterization of the lesional cell population.