Case Reports in Pathology / 2014 / Article / Tab 1

Case Report

Sclerosing Polycystic Adenosis of the Retromolar Pad Area: A Case Report

Table 1

A review of immunohistochemical investigations in SPA cases.

InvestigatorsMarkersImmunohistochemical reactivity

Fulciniti et al. (2010) [9]Collagen IV Enhanced lobular architecture
Cytokeratin 14Enhanced the ratio of apocrine cells present in the epithelial lining of lobular structures
Gross cystic disease fluid protein (GCFDP)Sebaceous cells

Gurgel et al. (2010) [8]Ki-67 Positive in less than 1% of cells
CKAE1/AE3, EMA, GCDFP-15Tubuloacinar elements
Estrogen, progesterone, and CK 34βE12 Negative
SMA, S100 Myoepithelial layer

Swelam (2010) [5]S100 Lesional ductal and spindle-shaped cells
Bcl-2Strong, diffuse cytoplasmic immunoreactivity in basal cells of neoplastic cells
Ki-67Sporadic positivity in Basal cells of neoplastic ductal epithelium
EBV Expression in neoplastic S100 positive cells

Meer and Altini (2008) [2]P63Peripheral layer of cells surrounding acini, ducts, and cystic spaces outlining these structures
AE1/AE3 In ductal lining cells of tubuloacinar elements
S100Ductal cells and spindled myoepithelial cells
AE1/AE3, CAM5.2, EMA, antimicrobial antibody, BRST-2, S100Luminal cells

Bharadwaj et al. (2007) [10]Cytokeratin In ductal and acinar elements
SMA, S100Myoepithelial layer

Skálová et al. (2006) [4]
CKAE1/AE3Positive in ductal and acinar cells
EMA, S100, antimitochondrial antibodyVariably positive
CEA, p53, and HER-2/neuNegative
GCDFP-15Acinar cells with coarse eosinophilic cytoplasm
Progesterone receptorsPositive in 15% to 20% of epithelial cells
Estrogen receptorsAt least focally in 5% of ductal cells in dysplastic and hyperplastic foci
SMA, P63, and calponinMyoepithelial layer

Gnepp et al. (2006) [7]Calponin, SMA, muscle specific actin, S100Myoepithelial layer