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Case Reports in Pathology
Volume 2015, Article ID 241308, 4 pages
Case Report

Anaplastic Transformation of Papillary Thyroid Cancer in the Retroperitoneum

1Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
2Department of Pathology, Veteran Administration Medical Center, La Jolla, 3350 La Jolla Village Drive (113), San Diego, CA 92161, USA

Received 6 July 2015; Accepted 2 August 2015

Academic Editor: Prashant Bavi

Copyright © 2015 James P. Solomon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Anaplastic thyroid carcinoma is an aggressive variant of thyroid cancer that in most cases arises from anaplastic transformation of terminally differentiated thyroid carcinomas. This process usually occurs in the thyroid or cervical lymph nodes. Anaplastic transformation in distant metastatic sites is exceedingly rare, only previously documented in a few case reports. We report a rare case of anaplastic transformation of papillary thyroid carcinoma within a large retroperitoneal metastasis in a 64-year-old male 30 years after the initial diagnosis.