Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pathology
Volume 2015 (2015), Article ID 609780, 5 pages
http://dx.doi.org/10.1155/2015/609780
Case Report

Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern

1Department of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, Colombia
2School of Medicine, University of Los Andes, Carrera 1 No. 18A-12, Bogotá 111711, Colombia
3Department of Pathology, Good Samaritan Regional Medical Center, 255 Lafayette Avenue, Suffern, NY 10901, USA
4Transplant and Hepatobiliary Surgical Service, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, Colombia
5School of Medicine, National University of Colombia, Carrera 45 No. 26-85, Bogotá 111711, Colombia

Received 8 October 2014; Revised 3 February 2015; Accepted 18 February 2015

Academic Editor: Hiroko Kuwabara

Copyright © 2015 Diana Castro-Villabón et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. A. Edmondson, “Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood,” A.M.A. Journal of Diseases of Children, vol. 91, no. 2, pp. 168–186, 1956. View at Google Scholar · View at Scopus
  2. A. Patonai, B. Erdélyi-Belle, A. Korompay et al., “Molecular characteristics of fibrolamellar hepatocellular carcinoma,” Pathology & Oncology Research, vol. 19, no. 1, pp. 63–70, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Torbenson, “Fibrolamellar carcinoma: 2012 update,” Scientifica, vol. 2012, Article ID 743790, 15 pages, 2012. View at Publisher · View at Google Scholar
  4. J. R. Craig, R. L. Peters, H. A. Edmondson, and M. Omata, “Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features,” Cancer, vol. 46, no. 2, pp. 372–379, 1980. View at Google Scholar · View at Scopus
  5. G. Seitz, A. Zimmermann, H. Friess, and M. W. Bchler, “Adult-type hepatocellular carcinoma in the center of a fibrolamellar hepatocellular carcinoma,” Human Pathology, vol. 33, no. 7, pp. 765–769, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Reuland, K. P. Aicher, H.-J. Brambs et al., “Incidental finding of a hepatic lesion: differential diagnostic problems for fibrolamellar hepatic carcinoma,” Journal of Nuclear Medicine, vol. 35, no. 8, pp. 1342–1346, 1994. View at Google Scholar · View at Scopus
  7. A. Okano, K. Hajiro, H. Takakuwa, and Y. Kobashi, “Fibrolamellar carcinoma of the liver with a mixture of ordinary hepatocellular carcinoma: a case report,” The American Journal of Gastroenterology, vol. 93, no. 7, pp. 1144–1145, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Okada, Y. I. Kim, K. Nakashima et al., “Fibrolamellar hepatocellular carcinoma coexistent with a hepatocellular carcinoma of common type: report of a case,” Surgery Today, vol. 23, no. 7, pp. 626–631, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Singh and B. Ramakrishna, “Combined hepatocellular carcinoma and fibrolamellar carcinoma presenting as two adjacent separate lesions in a young boy: first case report from Asia,” Case Reports in Hepatology, vol. 2013, Article ID 101862, 4 pages, 2013. View at Publisher · View at Google Scholar
  10. A. Patonai, B. Erdélyi-Belle, A. Korompay et al., “Claudins and tricellulin in fibrolamellar hepatocellular carcinoma,” Virchows Archiv, vol. 458, no. 6, pp. 679–688, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. N. D. Theise, “BFT. Pathology and Genetics of Tumours of the Digestive System,” http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/.
  12. K. A. Mitchell, “Hepatocellular carcinoma: histologic considerations: pure, mixed, and motley,” Journal of Clinical Gastroenterology, vol. 47, supplement, pp. S20–S26, 2013. View at Google Scholar
  13. V. Paradis, “Histopathology of hepatocellular carcinoma,” in Multidisciplinary Treatment of Hepatocellular Carcinoma, vol. 190 of Recent Results in Cancer Research, pp. 21–32, Springer, Berlin, Germany, 2013. View at Publisher · View at Google Scholar
  14. H. M. Ross, H. D. J. Daniel, P. Vivekanandan et al., “Fibrolamellar carcinomas are positive for CD68,” Modern Pathology, vol. 24, no. 3, pp. 390–395, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Durnez, C. Verslype, F. Nevens et al., “The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin,” Histopathology, vol. 49, no. 2, pp. 138–151, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. J. N. Honeyman, E. P. Simon, N. Robine et al., “Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma,” Science, vol. 343, no. 6174, pp. 1010–1014, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. M. V. Nesterova, N. Johnson, C. Cheadle et al., “Autoantibody cancer biomarker: extracellular protein kinase A,” Cancer Research, vol. 66, no. 18, pp. 8971–8974, 2006. View at Google Scholar