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Case Reports in Pathology
Volume 2016, Article ID 3741291, 5 pages
Case Report

Pulmonary Empty Spaces: Silicone Embolism—A Decade of Increased Incidence and Its Histological Diagnosis

1Pathology and Laboratory Medicine Department, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
2Department of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL, USA
3Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA
4Department of Pathology, Cleveland Clinic Florida, Weston, FL, USA

Received 9 October 2015; Revised 29 December 2015; Accepted 30 December 2015

Academic Editor: Piero Tosi

Copyright © 2016 Kirill Lyapichev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pulmonary embolism (PE) is a critical complication related to multiple disorders and different medical or cosmetic procedures. This case report presents two patients who were admitted for respiratory symptoms in the setting of previously receiving silicone injections for cosmetic purposes and were diagnosed with silicone pulmonary embolism. The relevance of including questions about all cosmetic procedures as a part of a medical history is highlighted, in particular about silicone injections. The diagnosis is confirmed by histological means. Additionally, our review showed the change of most common sites of silicone injections and a significant increase in cosmetic procedures causing silicone embolism during the past twelve years.