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Case Reports in Pathology
Volume 2016, Article ID 6762085, 4 pages
Case Report

Primary Neuroendocrine Carcinoma of the Breast: Histopathological Criteria, Prognostic Factors, and Review of the Literature

1Department of Radiotherapy, Oncology Center, Varna, Bulgaria
2Department of General and Clinical Pathology, Forensic Science and Deontology, Medical University, Varna, Bulgaria
3Department of General and Clinical Pathology, Oncology Center, Varna, Bulgaria

Received 25 July 2016; Revised 29 August 2016; Accepted 3 October 2016

Academic Editor: Tibor Tot

Copyright © 2016 Lena Marinova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present here a case of a 42-year-old woman diagnosed with primary neuroendocrine carcinoma of the breast (NECB). We discuss the importance of histological criteria for primary neuroendocrine mammary carcinoma, established by WHO in 2003 and 2012. After an overview of different cases of primary neuroendocrine carcinoma of the breast published in the literature, we present information about differential diagnosis, prognostic factors, and surgical and adjuvant treatment. Prognosis of NECB is not different from that of other invasive breast carcinomas and the most important prognostic factor is tumor grade (G). There is no standard treatment and patients should be treated similarly to patients with invasive ductal carcinoma, NOS (not otherwise specified), whose choice of therapy depends on tumor’s size, degree of differentiation, clinical stage, and hormonal status.