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Case Reports in Pathology
Volume 2016, Article ID 7318672, 4 pages
Case Report

Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review

1Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY, USA
2Department of Urology, University of Louisville School of Medicine, Louisville, KY, USA

Received 27 July 2016; Accepted 25 October 2016

Academic Editor: Fatemeh Mahjoub

Copyright © 2016 Houda Alatassi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature. We report a case of a 19-year-old man who presented with a large right testicle. Image studies showed a large retroperitoneal mass along with liver and lung metastases. Orchiectomy demonstrated a mixed germ cell tumor composed of yolk sac tumor, embryonal carcinoma, and mature and immature teratoma with a significant portion of nephroblastoma. The patient received chemotherapy and no recurrence was noted during six months of followup. WT-1 expression was also studied due to the lack of consistency of its expression in testicular nephroblastoma in the literature. We also present a discussion and review of the literature due to its rarity, which indicate an adverse prognosis for patients with nephroblastoma components receiving standard chemotherapeutical regimes for testicular germ cell tumors.