Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pathology
Volume 2017, Article ID 3427343, 5 pages
https://doi.org/10.1155/2017/3427343
Case Report

Gastric Medullary Carcinoma with Sporadic Mismatch Repair Deficiency and a TP53 R273C Mutation: An Unusual Case with Wild-Type BRAF

1Department of Pathology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA
2Department of Surgery, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA
3Department of Medicine, Division of Gastroenterology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA

Correspondence should be addressed to Mark A. Valasek; ude.dscu@kesalavm

Received 12 April 2017; Accepted 5 July 2017; Published 3 August 2017

Academic Editor: Lubos Holubec

Copyright © 2017 Brett M. Lowenthal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. T. Bosman, F. Carneiro, R. H. Hruban, and N. D. Theise, Eds., WHO Classification of Tumors of the Digestive System, IARC Press, Lyon, France, 4th edition, 2010.
  2. T. Minamoto, M. Mai, K. Watanabe et al., “Medullary carcinoma with lymphocytic infiltration of the stomach. Clinicopathologic study of 27 cases and immunohistochemical analysis of the subpopulations of infiltrating lymphocytes in the tumor,” Cancer, vol. 66, no. 5, pp. 945–952, 1990. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Dogan, B. Savas, G. Utkan, S. Bayar, A. Ensari, and F. Icli, “A rare gastric neoplasm: gastric medullary carcinoma,” Medical Oncology, vol. 28, no. 4, pp. 945–947, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Chetty, “Gastrointestinal cancers accompanied by a dense lymphoid component: an overview with special reference to gastric and colonic medullary and lymphoepithelioma-like carcinomas,” Journal of Clinical Pathology, vol. 65, no. 12, pp. 1062–1065, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Aslan, F. A. Yükrük, F. Buğdaycı Başal, and A. Durnalı, “Gastric medullary carcinoma: a rare case report,” Case Reports in Oncological Medicine, vol. 2016, 3 pages, 2016. View at Publisher · View at Google Scholar
  6. B.-J. Lü, M. Lai, L. Cheng, and etal., “Gastric medullary carcinoma, a distinct entity associated with microsatellite instability-H, prominent intraepithelial lymphocytes and improved prognosis,” Histopathology, vol. 45, no. 5, pp. 485–492, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Hirai, T. Yoshizawa, S. Morohashi et al., “Clinicopathological significance of gastric poorly differentiated medullary carcinoma,” Biomedical Research, vol. 37, no. 2, pp. 77–84, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Kastrinos and S. Syngal, “Screening patients with colorectal cancer for lynch syndrome: what are we waiting for?” Journal of Clinical Oncology, vol. 30, no. 10, pp. 1024–1027, 2012. View at Publisher · View at Google Scholar · View at Scopus