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Case Reports in Pathology
Volume 2017, Article ID 6714549, 5 pages
https://doi.org/10.1155/2017/6714549
Case Report

PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma

1Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
2Diagnose Anatomia Patologica e Citopatologia, Rio de Janeiro, RJ, Brazil

Correspondence should be addressed to Michelle S. Hirsch; gro.srentrap@1hcsrihm

Received 3 February 2017; Accepted 2 May 2017; Published 28 May 2017

Academic Editor: Dimosthenis Miliaras

Copyright © 2017 Michelle S. Hirsch and Alessandra F. Nascimento. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Mansouri, M. Hallonet, and P. Gruss, “Pax genes and their roles in cell differentiation and development,” Current Opinion in Cell Biology, vol. 8, no. 6, pp. 851–857, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. E. A. Morgan, O. Pozdnyakova, A. F. Nascimento, and M. S. Hirsch, “PAX8 and PAX5 are differentially expressed in B-cell and T-cell lymphomas,” Histopathology, vol. 62, no. 3, pp. 406–413, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Chi and J. A. Epstein, “Getting your Pax straight: pax proteins in development and disease,” Trends in Genetics, vol. 18, no. 1, pp. 41–47, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Plachov, K. Chowdhury, C. Walther et al., “Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland,” Development, vol. 110, no. 2, pp. 643–651, 1990. View at Google Scholar · View at Scopus
  5. M. Narlis, D. Grote, Y. Gaitan, S. K. Boualia, and M. Bouchard, “Pax2 and Pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney,” Journal of the American Society of Nephrology, vol. 18, no. 4, pp. 1121–1129, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. T. G. Kroll, P. Sarraf, L. Pecciarini et al., “PAX8-PPARγ1 fusion in oncogene human thyroid carcinoma,” Science, vol. 289, no. 5483, pp. 1357–1360, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Nonaka, Y. Tang, L. Chiriboga, M. Rivera, and R. Ghossein, “Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms,” Modern Pathology, vol. 21, no. 2, pp. 192–200, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Mittag, E. Winterhager, K. Bauer, and R. Grümmer, “Congenital hypothyroid female Pax8-deficient mice are infertile despite thyroid hormone replacement therapy,” Endocrinology, vol. 148, no. 2, pp. 719–725, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. R. Laury, R. Perets, H. Piao et al., “A comprehensive analysis of PAX8 expression in human epithelial tumors,” American Journal of Surgical Pathology, vol. 35, no. 6, pp. 816–826, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Moretti, L. J. Medeiros, K. Kunkalla, M. D. Williams, R. R. Singh, and F. Vega, “N-terminal PAX8 polyclonal antibody shows cross-reactivity with N-terminal region of PAX5 and is responsible for reports of PAX8 positivity in malignant lymphomas,” Modern Pathology, vol. 25, no. 2, pp. 231–236, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. M. M. Desouki, G. R. Post, D. Cherry, and J. Lazarchick, “PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms,” Clinical Medicine and Research, vol. 8, no. 2, pp. 84–88, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Carbone, A. Gloghini, M. Libra et al., “A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic and phenotypic markers characteristic of a germinal center B-cell origin,” Modern Pathology, vol. 19, no. 2, pp. 299–306, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Cerroni, L. El-Shabrawi-Caelen, R. Fink-Puches, P. E. LeBoit, and H. Kerl, “Cutaneous spindle-cell B-cell lymphoma: a morphologic variant of cutaneous large B-cell lymphoma,” American Journal of Dermatopathology, vol. 22, no. 4, pp. 299–304, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Wang, N. C. J. Sun, Y. Nozawa et al., “Histological and immunohistochemical characterization of extranodal diffuse large-cell lymphomas with prominent spindle cell features,” Histopathology, vol. 39, no. 5, pp. 476–481, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Abd El All, “Smooth muscle actin and s100p on non germinal centre diffuse large B cell lymphoma are adverse prognostic factors: pilot study,” Diagnostic Pathology, vol. 2, no. 1, article no. 9, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Horcher, A. Souabni, and M. Busslinger, “Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis,” Immunity, vol. 14, no. 6, pp. 779–790, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Y. Dong, P. Browne, Z. Liu, and M. Gangi, “PAX-5 is invariably expressed in B-cell lymphomas without plasma cell differentiation,” Histopathology, vol. 53, no. 3, pp. 278–287, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. K. C. Jensen, J. P. T. Higgins, K. Montgomery, G. Kaygusuz, M. Van De Rijn, and Y. Natkunam, “The utility of PAX5 immunohistochemistry in the diagnosis of undifferentiated malignant neoplasms,” Modern Pathology, vol. 20, no. 8, pp. 871–877, 2007. View at Publisher · View at Google Scholar · View at Scopus