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Case Reports in Pathology
Volume 2018, Article ID 1082956, 5 pages
Case Report

Subsequent Development of Desmoid Tumor after a Resected Gastrointestinal Stromal Tumor

1Department of Pathology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia
2Department of Pathology and Laboratory Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia

Correspondence should be addressed to Hatim Q. Al-Maghraby; moc.liamg@ygolohtaprd

Received 30 October 2017; Accepted 26 March 2018; Published 2 May 2018

Academic Editor: Yoji Nagashima

Copyright © 2018 Areen Abdulelah Murshid and Hatim Q. Al-Maghraby. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Desmoid tumors (deep fibromatosis) of the mesentery are rare mesenchymal tumors. They are often misdiagnosed, especially with a previous history of resection for gastrointestinal stromal tumor (GIST). Immunohistochemistry can help differentiate between these two tumors. In this article, we present a case we had encountered: a Desmoid tumor developing in a patient with a history of GIST 3 years ago. It is the first case of GIST with subsequent development of Desmoid tumor to be reported in Saudi Arabia. We discuss the two entities of Desmoid tumor and GIST by comparing their definitions, clinical presentations, histological features, immunohistochemistry stains, molecular pathogenesis, prognosis, and treatment. We also discuss the relationship between GIST and the subsequent development of Desmoid tumors and compare our case with case reports in literature.