IgG4-Related Sclerosing Cholangitis Involving the Intrahepatic Bile Ducts Diagnosed with Liver Biopsy

Figure 3

Histological findings in a patient with IgG4-related lymphadenopathy. (a) Low magnification showing expansion of the interfollicular zone (H&E). (b) At higher magnification, numerous plasma cells are identified in the interfollicular zones (H&E). (c, d) Strong infiltration of IgG4-positive cells, hot spot (c) (IgG4 immunostaining) and IgG-positive cells, hot spot (d) (IgG immunostaining). The IgG4 / IgG ratio is 92%. (e) A granulomatous focus, arranged in a ring-like fashion around a lymphoid follicle, is shown, a feature called perifollicular granuloma (H&E). (f) Another perifollicular granuloma, accompanied by numerous IgG4-positive cells (IgG4 immunostaining).

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