Placental Histomorphology in a Case of Double Trisomy 48,XXX,+18

Figure 2

Histologic examination of the placenta. Pseudovillous trophoblastic proliferation present at the undersurface of the chorionic plate [(a) magnification , H&E], highlighted by double E-cadherin (brown)/CD34 (red) immunostain [(b) magnification ]. Large irregular chorionic villi, showing trophoblastic pseudoinclusions and focal mineralization [(c) magnification , H&E]. Iron stain highlights the ferrugination [(d) magnification ]. Clusters of villous trophoblasts are seen [(e) magnification , H&E], highlighted by dual E-cadherin (brown) and CD34 (red) immunostain [(f) magnification ]. Perpendicularly oriented clusters of sclerotic chorionic villi are present in the chorion laeve [(g) magnification , H&E].

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