Abdominal Wall Clear Cell Carcinoma: Case Report of a Rare Event with Potential Diagnostic Difficulties

Table 1

Differential diagnosis of Mullerian clear cell carcinoma.

Diagnosis	Histologic features	Immunohistochemical markers
Mullerian clear cell carcinoma	Tubulocystic, papillary and solid patterns; small, frequently hyalinized papillae. Polygonal to cuboidal to flattened cells, with clear to eosinophilic cytoplasm; hobnail morphology.	Napsin-A, racemase, hepatocyte nuclear factor (HNF-1b)
High grade serous carcinoma	Branching papillary fronds, slit-like fenestrations, glandular complexity. Moderate to marked pleomorphism, prominent nucleoli, increased mitotic rate.	WT1, p53
Clear cell renal cell carcinoma	Tubulocystic or less commonly papillary pattern, cells with clear cytoplasm, distinct but delicate cell boundaries, small, thin walled, “chicken wire” vasculature.	CA-IX, RCC antigen, EMA, CD10
Mesothelioma	Epithelial or biphasic tumor with tubular, papillary or solid patterns. Tumor cells have moderate atypia and low mitotic rate.	Calretinin, CK5/6, WT-1, D2-40
Adrenocortical carcinoma	Different growth patterns; tumor cells with vacuolated to densely eosinophilic cytoplasm, usually marked nuclear atypia and increased mitotic rate.	SF-1, Melan-A, calretinin, S100, inhibin