Case Report

Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature

Table 1

Reported cases of secretory carcinoma of minor salivary glands and their clinical features.

AuthorSiteAge/SexClinical course (Duration)SizeLNI / DMTreatmentFollow-up (Duration)

Abe M, 2015 [5]Upper lip61/FPainless mass (1 year)0.8NANANA

Aizawa T, 2016 [6]Lower lip41/MSlow growth, painless (3 mo)1.5x1.3-/-SLNM (26 mo)

Bishop JA, 2013 [7] Buccal mucosa71/M NA1.0-/-SOnly 1 case of upper lip locally recurred.
Mean follow-up: 42 mo (4-85mo)
Hard Palate25/FNA-/-S
Soft Palate20/F0.9-/-S
Soft Palate86/F1.0-/-S
Soft Palate79/F0.7-/-S
Upper lip62/F0.3-/-S
Upper lip71/M0.6-/-S
Lower lip59/M0.9-/-S
Lower lip68/M0.5-/-S

Bissinger O, 2017 [8] Floor of mouth34/M0.8-/-SNo recurrence

Chiosea SI, 2012 [4] Soft palate-3 case, Buccal mucosa – 2 case, Tongue base- 1 case. Further clinical data not available

Connor A, 2012 [9] Oral cavity (NS)Mean:40 y
(14-77y)
NA1.8-/-S NA
Roof of mouth0.5-/-S
Inner cheekNA-/-S
Lip1.2-/-S

Cooper D, 2013 [10] Soft palate43/MSlow growing, painless2.5-/-SNo recurrence (14 mo)
Soft palate26/FPainless (7 mo)0.7-/-SNo recurrence (24 mo)

Din NU, 2016 [11] Buccal mucosa NA

Fehr A, 2011 [12] Soft Palate71/F NA
Oral mucosa43/M

Griffith C, 2011 [13] Upper lip15/M NANA-/-NANA

Guilmette J, 2017 [14] Buccal mucosa64/F NA0.6-/-NANA

Helkamaa T, 2015 [15] Hard palate35/MUlcerated, tender (6 mo)2.0x1.5-/-SNo recurrence (18 mo)

Hindocha N, 2017 [16] Upper lip27/FSlow growing (1y)1.5-/-SNo recurrence
Labial mucosa51/MAsymptomatic, firm (3y)-/-SNo recurrence

Kai K, 2017 [17] Buccal mucosa58/M NA3.0NASNo recurrence (1 y)

Keishling M, 2014 [18] Buccal mucosa5/F(4mo)1.5x1.5x1.3-/-SNA

Khurram SA, 2017 [19] Buccal mucosa, Lower lip and Soft palate- 1 case each. Further clinical data not available.

Kratochvil FJ, 2012 [20] Upper lip48/MSlow growth, painless1.0-/-SNo recurrence (8 mo)
Labial mucosa52/MPainless0.7x0.3-/-SNo recurrence (4 mo)

Laco J, 2013 [21] Upper lip34/FSlow growing, painless (2y)1.5-/-SNo recurrence (15 mo)

Luo W, 2014 [22] Hard palate41/FUlcerated crater2.0+/-S+RNo recurrence (10 mo)

Majewska H, 2015 [23] Hard palate54/MSlow growing, non tender (36 mo), aggressive (2 mo)2.0x1.0-/-S+RLocal recurrence (48 mo), LNM

Mariano FV, 2016 [24] and Projetti F, 2015 [25] each reported 1 case (no site specified). Further clinical data not available.

Roy S, 2018 [26] Upper lip54/MSlow growing, painless1.5-/-SNA
Tongue22/F NA1.5x1.5x1NASNA

Serrano ML, 2015 [27] Buccal mucosa41/FSlow growing0.5NANANA
Buccal mucosa50/MSlow growing0.5NANANA

Skalova A, 2010 [2] Buccal mucosa51/FSlow growing, painless (1y)1.0-/-SNo recurrence (4 y)
Soft palate48/MSlow growing1.0x1.5-/-SNo recurrence (9y)
Upper lip32/MPainless but grew in size1.0-/-S+RLNM (86 mo)

Skalova A, 2016 [28] Buccal mucosa31/F NA1.0-/-SNo recurrence (11 mo)
Buccal mucosa24/F1.0+/-SLNM, Local recurrence (2y)
Upper lip48/M1.0-/-SLocal recurrence (2 mo)
Lip50/M1.5NANANA
Retromolar gingiva69/F0.6-/-SNo recurrence (2y)
Retromolar gingiva73/M1.5x2.0x2.5+/-NANA
Lip62/F1.0-/-SNo recurrence (3 y)

Steven TM, 2015 [29] Upper lip44/F NANANASNA
Lower lip66/M NANANASNA
Hard palate54/M NANANAS+RNo recurrence (2 y)

Urano M, 2015 [30] Lip40/M(3 mo)1.2x1.1-/-NANo recurrence

Zardawi IM, 2014 [31] Upper lip66/M(6 mo)1.2x1.0x.08-/-SNo recurrence

LNI / DM: Lymph node involvement / Distant metastases before treatment, S: Surgery, R: Adjuvant radiotherapy, LNM: Lymph node metastases on follow-up, mo: Month, y: Year, NA: Data not available, +/-: Present/Absent