Involvement of Annexin A2 Expression and Apoptosis in Reverse Polarization of Invasive Micropapillary Carcinoma of the Breast

Figure 7

Immunohistochemistry of the background tumor components II. (a) A tubular component with scattered peripheral vacuoles is detected. H&E stain. (b) Luminal surface shows a distinct positivity, and a strong positivity is also observed at some rims of peripheral vacuoles, including the contact surface with the neighboring tumor cells (arrowheads). ANX A2 immunostain. (c) Luminal surface shows a distinct positivity, and a clear positivity is also found at some rims of the peripheral vacuoles with the strong ANX A2-positivity (arrowheads). EMA immunostain. (d) The immunoreactivity similar to that of (c) is seen (arrowheads). MUC-1 immunostain. The scale bars indicate 25 μm.

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