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Case Reports in Pediatrics
Volume 2011, Article ID 307857, 5 pages
http://dx.doi.org/10.1155/2011/307857
Case Report

Familial Recurrence of Cerebral Palsy with Multiple Risk Factors

1Division of Neurology, Department of Pediatrics, University of Alberta, 4-588 Edmonton Clinic Health Academy (ECHA), Edmonton, AB, Canada T6G 1C9
2Division of Hematology, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada T6G 1C9
3Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada T6G 2H7
4Division of Neurodevelopmental Pediatrics and Rehabilitative Medicine, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada T6G 0B7

Received 2 November 2011; Accepted 28 December 2011

Academic Editors: N. Deconinck and V. Soubasi

Copyright © 2011 Lawrence P. Richer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The recurrence of cerebral palsy in the same family is uncommon. We, however, report on two families with two or more affected siblings. In both families, numerous potential risk factors were identified including environmental, obstetric, and possible maternal effects. We hypothesize that multiple risk factors may lead to the increased risk of recurrence of cerebral palsy in families. Intrinsic and maternal risk factors should be investigated in all cases of cerebral palsy to properly counsel families on the risk of recurrence. Recent studies of genetic polymorphisms associated with cerebral palsy are considered with reference to our observations in these two families.