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Case Reports in Pediatrics
Volume 2012 (2012), Article ID 352751, 5 pages
Case Report

Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report

1Department of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, China
2Department of Pediatrics and Neonatology, Suez Canal University, Ismailia 41522, Egypt
3Department of Radiology, Third Xiangya Hospital of Central South University, Changsha, Hunan 410008, China

Received 26 June 2012; Accepted 3 October 2012

Academic Editors: C. Aldana-Valenzuela, J. Muraskas, and P. Strisciuglio

Copyright © 2012 Ahmed Omran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Primary hypothyroidism in the juvenile population generally leads to retardation of linear growth and delay or even arrest of puberty. However, in rare conditions, children with long-standing hypothyroidism present with signs of Van Wyk-Grumbach's syndrome (VWGS) which include juvenile hypothyroidism, delayed bone age, and pseudoprecocious puberty. We report a rare case of prepubertal male child from Asian origin, presented with long-standing untreated hypothyroidism complicated with VWGS and other complications including obesity, short stature, hepatomegaly, asymptomatic mild pericardial effusion, and pituitary hyperplasia.