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Case Reports in Pediatrics
Volume 2012, Article ID 752751, 4 pages
Case Report

Complete Corpus Callosum Agenesis: Can It Be Mild?

Don Carlo Gnocchi ONLUS Foundation, Piazzale R. Morandi 6, 20121 Milan, Italy

Received 18 June 2012; Accepted 29 July 2012

Academic Editors: M. Ehlayel and R. Nicholl

Copyright © 2012 Matteo Chiappedi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Corpus callosum agenesis is a relatively common brain malformation. It can be isolated or included in a complex alteration of brain (or sometimes even whole body) morphology. Etiology and pathogenetic mechanisms have been better understood in recent years due to the availability of more adequate animal models and the relevant progresses in developmental neurosciences. We present the case of a girl with a complete agenesis of the corpus callosum discovered at birth. She had mild learning difficulties, but reached satisfactory levels of autonomy after an individually tailored rehabilitative treatment. Her story is discussed in light of recent findings, which emphasize the possibility to exploit brain plasticity and the utility of an individually tailored approach, defined on the basis of a dialogue with the family and the patient.