| | Sl. no. | System involved | Clinical features of Emanuel syndrome |
| | 1 | Growth and development | Pre and postnatal growth retardation, delayed speech, and language development (more commonly) |
| | 2 | Craniofacial | Microbrachycephaly, prominent forehead, epicanthal folds, downslanting palpebral fissures, broad and flat nasal bridge, long pronounced philtrum, abnormal auricles, preauricular ear pits and/or tags 76%, deafness, and otitis media |
| | 3 | CNS | Microcephaly present most commonly, seizures, failure to thrive, and delayed pschomotor development |
| | 4 | Cardiac | 60% individuals with congenital heart defects like atrial septal defect, ventricular septal defect, Tetralogy of Fallot, and patent ductus arteriosus |
| | 5 | Genitointestinal | Diaphragmatic hernia, anal atresia, inguinal hernias, biliary atresia, small penis 64%, and cryptorchidism 46% |
| | 6 | Musculoskeletal | Centrally based hypotonia most commonly, congenital hip dislocation, arachnodactyly, club foot and joint, syndactyly of the toes, delayed bone age, and hyperextensibility of joints |
| | 7 | Oral findings | Cleft palate 50%, micrognathia 60%, angular mouth pits, bifid uvula, and facial asymmetry |
| | 8 | Immunological | Congenital immunological deficiency |
| | 9 | Renal | Renal defects 36% |
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