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Case Reports in Pediatrics
Volume 2014, Article ID 704398, 3 pages
http://dx.doi.org/10.1155/2014/704398
Case Report

Six-Digit CPK and Mildly Affected Renal Function in McArdle Disease

1University of Iowa Children’s Hospital, Iowa City, IA 52242, USA
2St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USA
3The Unterberg Children’s Hospital at Monmouth Medical Center, Drexel University College of Medicine, Long Branch, NJ 07740, USA

Received 12 July 2014; Accepted 8 September 2014; Published 9 October 2014

Academic Editor: Anibh Martin Das

Copyright © 2014 George Spyropoulos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A previously healthy, white 12-year-old girl presented with diffuse body aches and poor perfusion. She developed severe respiratory failure and marked rhabdomyolysis and was mechanically ventilated. Although her CPK peaked at 500,000 IU/L, her renal function was mildly affected and her creatinine did not exceed the 0.8 mg/dL. The rhabdomyolysis was gradually resolved following aggressive fluid hydration. The patient did not require dialysis and made a complete recovery. Genetic studies revealed the diagnosis of McArdle disease.