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Case Reports in Pediatrics
Volume 2014, Article ID 851392, 4 pages
http://dx.doi.org/10.1155/2014/851392
Case Report

Hodgkin’s Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child

1Unit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, 30000 Fez, Morocco
2Unit of Pediatric Hematology-Oncology, Department of Pediatrics, Mother-Child Hospital, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University of Sidi Mohamed Ben Abdellah, BP 1893, Km 2.200, Sidi Hrazem Road, 30000 Fez, Morocco

Received 11 July 2014; Revised 13 September 2014; Accepted 16 September 2014; Published 29 September 2014

Academic Editor: Yusuke Shiozawa

Copyright © 2014 Sarra Benmiloud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, responsible for extensive phagocytosis of hematopoietic cells and causing a multisystem organ failure. If lymphomas are common causes of HLH, the association with Hodgkin’s lymphoma is rarely described in children. We report a case of a 9-year-old boy presenting with HLH as an initial manifestation of Hodgkin’s lymphoma. He has been suffering from persistent high fever, asthenia, weight loss, and hepatosplenomegaly with no lymphadenopathy. The diagnosis of HLH secondary to infectious disease was initially worn. The patient received high-dose intravenous immunoglobulin with broad-spectrum antibiotics. However, his state got worse with the onset of dry cough and pleural effusion. Histopathologic examination of pleural fluid showed the presence of Reed-Sternberg cells. The outcome was favorable after treatment by corticosteroid and chemotherapy. Hodgkin’s lymphoma revealed by HLH is a source of delayed diagnosis and should be borne in mind in children.