Case Report
Neonatal Hepatitis as First Manifestation of Hyperimmunoglobulinemia D Syndrome
Table 1
Investigations performed in the neonatal period.
| | Examination | Test result |
| | Haemoglobin (range) | 5.0–9.5 mmol/L | | Leucocytes (highest) | 45 × 109/L | | Thrombocytes (lowest) | 17 × 109/L | | CRP (highest) | 110 mg/L | | Bilirubin total (highest) | 552 µmol/L | | Bilirubin conjugated (highest) | 392 µmol/L | | ALAT (highest) | 281 U/L | | Alkaline phosphatase (highest) | 483 U/L | | Lactate dehydrogenase | 3235 U/L | | Urate | 0.38 mmol/L | | Lactate | 2.2 mmol/L | | Blood culture | Negative | | Blood smear | Extramedullary haematopoiesis
no lymphoblasts | | Bone marrow aspiration | No malignancy | | CMV serology | Negative | | CMV PCR in blood and urine | Negative | | EBV serology | Negative | | Toxoplasmosis serology | Negative | | VZV serology | Negative | | Urine metabolic screen | Normal | | X-ray thorax | No infiltrates | | X-ray abdomen | Normal | | US abdomen | Marked hepatomegaly | | CT thorax and abdomen | Marked hepatomegaly | | US cerebrum | 2.2 × 2.5 cm echogenic process | | CT cerebrum |
Haemorragia in posterior fossa | | Electrocardiogram | Normal | | Echocardiography | Normal | | Lumbar puncture | Unsuccessful |
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