Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pediatrics
Volume 2014, Article ID 980401, 5 pages
http://dx.doi.org/10.1155/2014/980401
Case Report

Can Attention Deficits Predict a Genotype? Isolate Attention Difficulties in a Boy with Klinefelter Syndrome Effectively Treated with Methylphenidate

1Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
2Division of Psychology, Department of Humanities and Social Sciences, University of Messina, Via Concezione, No. 6/8, 98100 Messina, Italy
3IRCCS Stella Maris, Scientific Institute Child Neurology and Psychiatry, Viale del Tirreno, No. 331, 56018 Calambrone, Pisa, Italy

Received 2 April 2014; Revised 15 June 2014; Accepted 30 June 2014; Published 19 August 2014

Academic Editor: Karen Kowal

Copyright © 2014 Antonella Gagliano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. C. Giltay and M. C. Maiburg, “Klinefelter syndrome: clinical and molecular aspects,” Expert Review of Molecular Diagnostics, vol. 10, no. 6, pp. 765–776, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. M. P. Vawter, P. D. Harvey, and L. E. DeLisi, “Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition,” American Journal Medical Genetics B, vol. 144, no. 6, pp. 728–734, 2007. View at Google Scholar
  3. D. V. Bishop and G. Scerif, “Klinefelter syndrome as a window on the aetiology of language and communication impairments in children: the neuroligin-neurexin hypothesis,” Acta Paediatrica, International Journal of Paediatrics, vol. 100, no. 6, pp. 903–907, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. J. N. Giedd, L. S. Clasen, G. L. Wallace et al., “XXY (Klinefelter syndrome): a pediatric quantitative brain magnetic resonance imaging case-control study,” Pediatrics, vol. 119, no. 1, pp. e232–e240, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. L. Ross, D. P. Roeltgen, G. Stefanatos et al., “Cognitive and motor development during childhood in boys with Klinefelter syndrome,” American Journal of Medical Genetics A, vol. 146, no. 6, pp. 708–719, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Samango-Sprouse, “Expansion of the phenotypic profile of the young child with XXY,” Pediatric Endocrinology Reviews, vol. 8, supplement 1, pp. 160–168, 2010. View at Google Scholar · View at Scopus
  7. K. Kompus, R. Westerhausen, L.-G. Nilsson et al., “Deficits in inhibitory executive functions in Klinefelter (47, XXY) syndrome,” Psychiatry Research, vol. 189, no. 1, pp. 135–140, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. N. R. Tartaglia, N. Ayari, C. Hutaff-Lee, and R. Boada, “Attention-deficit hyperactivity disorder symptoms in children and adolescents with sex chromosome aneuploidy: XXY, XXX, XYY, and XXYY,” Journal of Developmental and Behavioral Pediatrics, vol. 33, no. 4, pp. 309–318, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. D. V. M. Bishop, P. A. Jacobs, K. Lachlan et al., “Autism, language and communication in children with sex chromosome trisomies,” Archives of Disease in Childhood, vol. 96, no. 10, pp. 954–959, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Tartaglia, L. Cordeiro, S. Howell, R. Wilson, and J. Janusz, “The spectrum of the behavioral phenotype in boys and adolescents 47,XXY (Klinefelter syndrome),” Pediatric Endocrinology Reviews, vol. 8, pp. 151–159, 2010. View at Google Scholar · View at Scopus
  11. M. F. Messina, D. L. Sgrò, T. Aversa, M. Pecoraro, M. Valenzise, and F. de Luca, “A characteristic cognitive and behavioral pattern as a clue to suspect Klinefelter syndrome in prepubertal age,” The Journal of the American Board of Family Medicine, vol. 25, no. 5, pp. 745–749, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. G. J. DuPaul, T. J. Power, A. D. Anastopoulos, and R. Reid, ADHD Rating Scale—IV: Checklists, Norms, and Clinical Interpretations, The Guilford Press, New York, NY, USA, 1998.
  13. C. K. Conners, Conners Rating Scales: Revised Technical Manual, Multi-Health Systems, North Tonawanda, NY, USA, 1997.
  14. W. Guy, ECDEU Assessment Manual for Psychopharmacology, Revised, Publication ADM 76-338, U.S. Department of Health, Education, and Welfare, Bethesda, Md, USA, 1976.
  15. M. Kovacs, “Rating scales to assess depression in school-aged children,” Acta Paedopsychiatrica, vol. 46, no. 5-6, pp. 305–315, 1981. View at Google Scholar · View at Scopus
  16. J. S. March, J. D. Parker, K. Sullivan, P. Stallings, and K. Conners, “The multidimensional anxiety scale for children (MASC),” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 36, pp. 554–565, 1997. View at Google Scholar
  17. S. Di Nuovo, “Attenzione e concentrazione. 7 test e 12 training di potenziamento,” Ed Erikson, Trento, Italy, 2000.
  18. N. R. Lee, G. L. Wallace, L. S. Clasen et al., “Executive function in young males with Klinefelter (XXY) syndrome with and without comorbid attention-deficit/hyperactivity disorder,” Journal of the International Neuropsychological Society, vol. 22, pp. 1–9, 2011. View at Google Scholar
  19. D. H. Geschwind, K. B. Boone, B. L. Miller, and R. S. Swerdloff, “Neurobehavioral phenotype of Klinefelter syndrome,” Mental Retardation and Developmental Disabilities Research Reviews, vol. 6, no. 2, pp. 107–116, 2000. View at Google Scholar
  20. D. R. Coghill, S. Seth, S. Pedroso, T. Usala, J. Currie, and A. Gagliano, “Effects of methylphenidate on cognitive functions in children and adolescents with attention-deficit/hyperactivity disorder: evidence from a systematic review and a meta-analysis,” Biological Psychiatry, 2013. View at Publisher · View at Google Scholar
  21. K. Cornish, A. Steele, C. R. C. Monteiro, A. Karmiloff-Smith, and G. Scerif, “Attention deficits predict phenotypic outcomes in syndrome-specific and domain-specific ways,” Frontiers in Psychology, vol. 3, article 227, 2012. View at Publisher · View at Google Scholar · View at Scopus