Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature

Table 1

Laboratory results of liver function.

(a)

Date	Episode	ALT; (normal, <35); UI/L	AST; (normal, <45); UI/L	Total bilirubin; (normal, 0–1.2) mg/dL	Alkaline phosphatase; (normal, 30–355); UI/L	Prothrombin activity; (80–120); %
18/12/10	Control	13	21	0.3	56	101
26/02/11	Jaundice, Coluria, acholia; MPH was discontinued	423	857	4	339	71
04/04/11	Worsening coagulopathy	182	361	12.2	304	36

(b)

Date	Episode	ALT; (normal, 30–65); UI/L	AST; (normal, 15–37); UI/L	GGT; (normal, 5–85); UI/L	Total bilirubin; (normal, 0.2–1.4) mg/dL	Alkaline phosphatase; (normal, 42–362); UI/L	Prothrombin activity; (80–120); %
04/05/11	Arrived to Hospital Universitario La Paz	138	310	29	28.7		13
05/05/11	Onset of NAC	141	332	21	36.9	275	17
06/05/11	Encephalopathy medium-severe intensity with hyperammonemia	122	269	29	27		27
07/05/11		119	238	29	27.4		19
08/05/11	Hepatic transplantation	110	243	30	26.9		21
08/05/11	After hepatic transplantation	480	792	44	10.8		41
09/05/11		534	996	48	6.9		51
10/05/11		389	373	43	3.9		97
11/05/11		348	213	135	5.4		105
12/05/11		356	185		5.4		94
13/05/11		310	124	494	5.6		102
14/05/11		259	78	511	4.7		108
15/05/11		269	104	737	4.9		109
16/05/11		260	93	703	4.1		118
17/05/11		377	193	1106	4.7		109
18/05/11		459	194	1099	4.4		113
19/05/11		478	188	1139	3.9		107
20/05/11	Discharge from ICU	338	86	946	3		115
21/05/11		279	64	939	2.7		105
22/05/11		206	39	782	2.4		104
23/05/11		165	30	745	2.3	260	99
24/05/11		127	25	629	2		95
26/05/11		111	35	604	1.8		103
28/05/11		93	33	522	1.6		97
31/05/11		75	36	417	1.4		108
03/06/11		82	39	351	1.2	192	119
07/06/11	Discharge from the hospital	61	22	305	1.3	189	113
10/06/11		42	25	262	2.13	220	105
20/06/11		23	20	152	1.14	188	104

NAC: N-acetylcysteine.