Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pediatrics
Volume 2016, Article ID 3495910, 4 pages
http://dx.doi.org/10.1155/2016/3495910
Case Report

Fetal Valproate Syndrome with Limb Defects: An Indian Case Report

1Rare Disease Clinic, Department of Pediatrics, SMS Medical College and Hospitals, Jaipur, Rajasthan, India
2Accident Emergency, Department of Pediatrics, SMS Medical College and Hospitals, Jaipur, Rajasthan, India
3Department of Pediatrics, SMS Medical College and Hospitals, Jaipur, Rajasthan, India

Received 25 July 2016; Revised 28 September 2016; Accepted 16 October 2016

Academic Editor: Piero Pavone

Copyright © 2016 Manisha Goyal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Dalens, E.-J. Raynaud, and J. Gaulme, “Teratogenicity of valproic acid,” The Journal of Pediatrics, vol. 97, no. 2, pp. 332–333, 1980. View at Publisher · View at Google Scholar · View at Scopus
  2. H. H. Ardinger, J. F. Atkin, R. D. Blackston et al., “Verification of the fetal valproate syndrome phenotype,” American Journal of Medical Genetics, vol. 29, no. 1, pp. 171–185, 1988. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Jentink, M. A. Loane, H. Dolk et al., “Valproic acid monotherapy in pregnancy and major congenital malformations,” The New England Journal of Medicine, vol. 362, no. 23, pp. 2185–2193, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Tomson, D. Battino, E. Bonizzoni et al., “Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry,” The Lancet Neurology, vol. 10, no. 7, pp. 609–617, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Campbell, F. Kennedy, A. Russell et al., “Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland epilepsy and pregnancy registers,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 85, no. 9, pp. 1029–1034, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Hernández-Díaz, C. R. Smith, A. Shen et al., “Comparative safety of antiepileptic drugs during pregnancy,” Neurology, vol. 78, no. 21, pp. 1692–1699, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Morrow, A. Russell, E. Guthrie et al., “Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 77, no. 2, pp. 193–198, 2006. View at Publisher · View at Google Scholar
  8. A. Faiella, M. Wernig, G. G. Consalez et al., “A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression,” Human Molecular Genetics, vol. 9, no. 2, pp. 227–236, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Dean, Z. Robertson, V. Reid et al., “Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRR,” American Journal of Medical Genetics, Part A, vol. 143, no. 19, pp. 2303–2311, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. K. L. Jones, Smith's Recognizable Patterns of Human Malformation, WB Saunders Company, Philadelphia, Pa, USA, 5th edition, 1997.
  11. E. K. Schorry, S. G. Oppenheimer, and H. M. Saal, “Valproate embryopathy: clinical and cognitive profile in 5 siblings,” American Journal of Medical Genetics, vol. 133, no. 2, pp. 202–206, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. K. J. Meador, G. A. Baker, N. Browning et al., “Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study,” The Lancet Neurology, vol. 12, no. 3, pp. 244–252, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Rodríguez-Pinilla, I. Arroyo, J. Fondevilla, M. J. García, and M. L. Martínez-Frías, “Prenatal exposure to valproic acid during pregnancy and limb deficiencies: a case-control study,” American Journal of Medical Genetics, vol. 90, no. 5, pp. 376–381, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. M. A. Guven, C. Batukan, S. Ceylaner, G. Ceylaner, and M. Uzel, “A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 19, no. 2, pp. 115–117, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Sharony, A. Garber, D. Viskochil et al., “Preaxial ray reduction defects as part of valproic acid embryofetopathy,” Prenatal Diagnosis, vol. 13, no. 10, pp. 909–918, 1993. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Jäger-Roman, A. Deichl, S. Jakob et al., “Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid,” The Journal of Pediatrics, vol. 108, no. 6, pp. 997–1004, 1986. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Crawford, R. Appleton, T. Betts et al., “The women with epilepsy guidelines development group. Best practice guidelines for the management of women with epilepsy,” Seizure, vol. 8, no. 4, pp. 201–217, 1999. View at Publisher · View at Google Scholar