A Fatal Case of Congenital Langerhans Cell Histiocytosis with Disseminated Cutaneous Lesions in a Premature Neonate

Figure 2

Histopathology of a cutaneous lesion showing histiocytic cell infiltration in the epidermis and dermis as well as under the stratum corneum ((a); HE stain), which were stained positive for CD1a (b) (original magnification, ×400), magnified photos showing characteristic folded “coffee bean” nucleus ((c); HE stain), positive S100 staining (d), and positive CD1a (e). Staining for E-cadherin and CD56 was negative (data not shown).

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