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Case Reports in Pediatrics
Volume 2017, Article ID 5637503, 3 pages
Case Report

Acute Hemorrhagic Edema of Infancy after Coronavirus Infection with Recurrent Rash

1Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA
2Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA

Correspondence should be addressed to Eric Zwemer; ude.cnu.dem@remewz_cire

Received 31 July 2016; Revised 26 October 2016; Accepted 20 November 2016; Published 24 January 2017

Academic Editor: Abraham Gedalia

Copyright © 2017 Hannah Chesser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpura, particularly when accompanied by fever, is a worrisome finding in children. Acute hemorrhagic edema of infancy (AHEI) is a benign type of small-vessel leukocytoclastic vasculitis that presents with progressive purpura and has an excellent prognosis. Patients with AHEI present with large, target-like purpuric plaques affecting the face, ear lobes, and extremities. While the rapid onset of these skin findings can be dramatic, the child with AHEI is usually well appearing with reassuring laboratory testing. We describe a case of a previously healthy 8-month-old female who presented with progressive purpura in a nondependent distribution, low-grade fevers, and extremity swelling. An extensive workup was performed prior to making the diagnosis of AHEI. Coronavirus was implicated as the likely triggering pathogen, and the patient suffered a recurrence of purpuric rash and swelling several weeks after her initial presentation.