Case Report

Diffuse Adenomatosis and Hepatocellular Carcinoma Treated with Liver Transplantation in an Adolescent Female with Kabuki Syndrome with a Novel KMT2D Gene Mutation

Figure 2

(a) Photomicrograph of the large hepatic mass reveals a well-differentiated hepatocellular neoplasm with mild cytologic atypia. A single unpaired vessel is present at the right-hand side of the image (hematoxylin and eosin, 20x magnification). (b) The large hepatic mass shows a focally disrupted reticulin meshwork with thickened hepatocyte trabeculae, consistent with a well-differentiated hepatocellular carcinoma (reticulin stain, 20x magnification). (c) The explanted specimen reveals a large heterogeneous mass with areas of hemorrhage and necrosis, occupying nearly the entire left hepatic lobe (hepatocellular carcinoma arising from a hepatic adenoma). Multiple small hepatic adenomas are present within the right hepatic lobe (arrows).
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